Bring bold southern flavor into your kitchen with this comforting twist on classic spaghetti. Cajun beef spaghetti in creamy three-cheese Parmesan sauce is a dish that hits every note: rich, spicy, savory, and irresistibly cheesy. Picture tender strands of spaghetti wrapped in a silky blend of cream cheese, mozzarella, and nutty Parmesan, with smoky Cajun-seasoned ground beef tucked in every bite. It’s comfort food with a little kick and a whole lot of personality.

Whether you’re cooking for a family dinner or impressing guests on a casual weekend, this pasta dish is the perfect balance of heat and creaminess. It’s hearty enough to satisfy, easy enough to make on a weeknight, and flavorful enough to become a repeat favorite.

Why You’ll Love This Cajun Beef Spaghetti in Creamy Three-Cheese Parmesan Sauce

This dish isn’t just another spaghetti recipe. The creamy three-cheese sauce coats every noodle in decadent richness, while the Cajun beef gives it a smoky, spicy backbone that makes each forkful exciting. It’s a fusion of southern-style spice and Italian-inspired indulgence that you won’t forget after the first bite.

Perfect for cozy nights in, this recipe offers comfort food satisfaction with elevated flavor. The three-cheese combination brings depth, while the Cajun seasoning adds character without overwhelming. You can even adjust the heat level to your liking. It reheats well, making it ideal for meal prep or next-day leftovers.

What Kind of Parmesan Should I Use?

For the best flavor and melt, go with freshly grated Parmesan straight off the block. Pre-shredded versions often contain anti-caking agents that don’t melt as smoothly, which can affect the texture of your sauce. If you’re short on time, a good quality deli-grated Parmesan is the next best option. Just avoid the powdered kind in the green shaker – it won’t do this sauce justice.

Ingredients for the Cajun Beef Spaghetti in Creamy Three-Cheese Parmesan Sauce

To make this creamy and flavor-packed pasta, you’ll need a mix of pantry staples and a few fresh ingredients. Each item plays a crucial role in building that savory, cheesy, spicy goodness that makes this dish so craveable.

Spaghetti: The classic pasta base that holds up perfectly to the rich cheese sauce.
Ground beef: Brings the heartiness and soaks up all the Cajun spices beautifully.
Cajun seasoning: Adds that smoky, spicy, southern-inspired kick.
Garlic: Fresh garlic enhances the savoriness of the sauce.
Onion: Brings depth and aromatic sweetness.
Cream cheese: The creamy base that makes the sauce ultra-smooth.
Mozzarella cheese: Melts into the sauce for gooey, stretchy goodness.
Parmesan cheese: Sharp and nutty, it finishes the sauce with that iconic cheesy punch.
Heavy cream: Rounds out the sauce with luscious richness.
Olive oil: Used to sauté the beef and aromatics.
Salt & black pepper: Essential for seasoning to taste.

Cajun Beef Spaghetti in Creamy Three-Cheese Parmesan Sauce 2

How To Make the Cajun Beef Spaghetti in Creamy Three-Cheese Parmesan Sauce

Step 1: Cook the Pasta

Bring a large pot of salted water to a boil and cook the spaghetti until al dente. Drain and set aside.

Step 2: Brown the Beef

Heat olive oil in a large skillet over medium heat. Add the ground beef and break it up with a spatula. Cook until browned and no longer pink. Drain excess grease.

Step 3: Sauté the Aromatics

To the same skillet, add chopped onion and minced garlic. Sauté until fragrant and translucent, about 3 minutes.

Step 4: Add Cajun Flavor

Stir in the Cajun seasoning and let it bloom in the pan for a minute. This deepens the spice flavor.

Step 5: Build the Sauce

Reduce the heat to low. Add cream cheese and heavy cream, stirring constantly until smooth and creamy. Then add the mozzarella and Parmesan cheeses, mixing until fully melted and velvety.

Step 6: Combine and Serve

Add the cooked spaghetti back into the skillet and toss everything together until the noodles are fully coated and the beef is well distributed. Serve immediately with a sprinkle of extra Parmesan if you’d like.

Serving and Storing This Cajun Beef Spaghetti in Creamy Three-Cheese Parmesan Sauce

This dish is perfect for feeding a crowd or making ahead for a week’s worth of comforting meals. It generously feeds 6 people and is rich enough to satisfy with just one bowl. Serve it hot, straight from the skillet, and you’ll be met with happy faces all around.

To store leftovers, let the spaghetti cool completely, then place it in an airtight container and refrigerate for up to 4 days. When reheating, add a splash of cream or milk to bring the sauce back to its original silky texture. It can also be frozen for up to 2 months, though the texture of the cheese sauce may change slightly upon thawing.

What to Serve With Cajun Beef Spaghetti?

Garlic Bread with Herbs

A warm slice of garlic bread is the classic partner to any creamy pasta. Add chopped parsley and a sprinkle of Parmesan for extra flair.

Caesar Salad

The crispness of romaine, tangy dressing, and crunchy croutons offer a cool contrast to the rich and spicy pasta.

Roasted Brussels Sprouts

Roasting them brings out their natural sweetness, which balances the Cajun spice of the spaghetti beautifully.

Creamy Cucumber Salad

A fresh cucumber salad with a sour cream or yogurt dressing gives your plate a cooling touch.

Parmesan Roasted Broccoli

Crispy and cheesy broccoli adds another veggie option that doesn’t compete with the flavors.

Southern Cornbread

If you’re leaning into the Cajun roots, a piece of warm, buttery cornbread fits the theme perfectly.

Balsamic Glazed Carrots

Roasted carrots with a balsamic drizzle provide a lightly sweet side that balances the heat.

Iced Sweet Tea

Keep it simple and Southern with a cold glass of sweet tea to wash it all down.

Want More Pasta Ideas?

If you loved this Cajun Beef Spaghetti in Creamy Three-Cheese Parmesan Sauce, you’re going to want to explore these other savory and satisfying pasta dishes next:

Try the Creamy Beef and Shells Recipe for a quick weeknight option packed with flavor.
Our Stovetop Creamy Ground Beef Pasta is another cozy classic perfect for busy nights.
The Creamy Ground Beef Alfredo Pasta brings rich, velvety comfort with every bite.
Need something ultra cheesy? Cheesy Baked Tortellini with Meat Sauce is layered with flavor.
Don’t miss the Cheesesteak Tortellini in Rich Provolone Sauce for a hearty twist on Philly flavors.

Save This Recipe For Later

📌 Save this recipe to your Pinterest dinner board so you can make it again anytime you crave something comforting with a Cajun kick.

And when you try it, let me know in the comments how it went. Did you spice it up even more? Add mushrooms or swap cheeses? I love hearing your takes on these recipes.

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