Cajun Chicken Spaghetti in Creamy Garlic Mozzarella Sauce

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There’s something incredibly comforting about a big plate of spaghetti, but when you bring Cajun spices, juicy chicken, and a rich, garlicky mozzarella sauce into the mix, it turns dinner into something extraordinary. This Cajun Chicken Spaghetti in Creamy Garlic Mozzarella Sauce isn’t just flavorful—it’s indulgent in all the best ways.

What makes this dish stand out is the balance between heat and creaminess. The Cajun seasoning brings that bold Southern flavor, while the mozzarella garlic sauce wraps it in smooth, savory comfort. It’s one of those meals that feels like a warm hug after a long day.

Why You’ll Love This Cajun Chicken Spaghetti

You’ll love how this meal packs flavor without needing complicated steps. It’s quick enough for a weeknight but impressive enough to serve guests. The Cajun spices add a kick that makes it anything but boring, and that creamy sauce will have you going back for seconds. Plus, it’s a one-pan kind of dinner if you plan smartly, so cleanup is a breeze.

This recipe is perfect when you want to shake up your pasta routine. It feels like something from your favorite Southern bistro, right in your kitchen.

What Kind of Chicken Should I Use?

Boneless, skinless chicken breasts are the most common go-to and work perfectly for this recipe. Slice them thinly for even cooking and maximum flavor absorption. If you have boneless thighs on hand, they can add a little extra juiciness. Just make sure to season well and don’t skimp on the sear. That golden crust holds all the smoky Cajun flavor and helps build the base of your sauce.

Ingredients for the Cajun Chicken Spaghetti in Creamy Garlic Mozzarella Sauce

To build bold flavor and velvety texture, the ingredients in this Cajun Chicken Spaghetti work together like a dream. You don’t need anything fancy—just a few pantry staples and some cheese magic.

• Spaghetti
• Chicken breasts
• Cajun seasoning
• Olive oil
• Butter
• Garlic cloves
• Heavy cream
• Mozzarella cheese
• Parmesan cheese
• Chicken broth
• Salt and pepper
• Fresh parsley

Spaghetti is the base of this recipe, soaking up the rich sauce and making each bite hearty. Chicken breasts are protein-packed and ideal for searing with Cajun seasoning. Cajun seasoning is key for heat and smoky depth. Olive oil and butter help brown the chicken and flavor the sauce. Garlic cloves infuse the cream with irresistible aroma, while heavy cream makes everything luxuriously smooth. Mozzarella gives the sauce that signature melty stretch, and a little Parmesan brings nutty sharpness. Chicken broth thins out the sauce without losing richness. Finish with salt and pepper to balance and fresh parsley for a pop of color and freshness.

How To Make the Cajun Chicken Spaghetti in Creamy Garlic Mozzarella Sauce

Step 1: Season and Sear the Chicken

Coat your chicken slices generously with Cajun seasoning. Heat olive oil in a skillet and sear the chicken until golden and cooked through. Remove and set aside.

Step 2: Cook the Pasta

Bring salted water to a boil and cook spaghetti according to package directions. Drain and set aside, saving about a cup of the pasta water.

Step 3: Build the Creamy Garlic Sauce

In the same skillet, melt butter and sauté minced garlic until fragrant. Pour in the chicken broth and heavy cream, stirring to blend. Add the mozzarella and Parmesan cheese, whisking until the sauce becomes silky and smooth.

Step 4: Combine Everything

Return the cooked chicken to the pan and toss in the drained spaghetti. If the sauce feels too thick, stir in some reserved pasta water. Let everything simmer together for a couple of minutes so the flavors meld.

Step 5: Serve and Garnish

Season with additional salt and pepper if needed. Top with chopped fresh parsley and serve hot straight from the pan.

How to Serve and Store Cajun Chicken Spaghetti in Creamy Garlic Mozzarella Sauce

This dish is best served hot and creamy, straight out of the skillet. As it sits, the sauce will thicken a bit, which makes leftovers even more luscious. If you’re planning a family-style meal, bring the whole skillet to the table and let everyone dig in. It feeds about four hearty servings and can easily be doubled for a crowd.

To store leftovers, let the spaghetti cool completely before transferring to an airtight container. It keeps well in the fridge for up to 3 days. Reheat gently on the stove or in the microwave, adding a splash of chicken broth or cream to bring back its silky texture.

What to Serve With Cajun Chicken Spaghetti?

Garlic Bread

Nothing beats dunking crispy garlic bread into that creamy mozzarella sauce. It’s the perfect crunchy side.

Roasted Broccoli

The slightly bitter char of roasted broccoli balances the richness of the sauce. A great way to sneak in some greens.

Caesar Salad

Crisp romaine, tangy dressing, and crunchy croutons bring refreshing contrast to the creamy pasta.

Corn on the Cob

Sweet and buttery corn complements the spice of the Cajun chicken beautifully.

Creamed Spinach

If you’re doubling down on decadence, creamed spinach is a warm, velvety pairing.

Sautéed Zucchini

Quickly cooked zucchini brings lightness and color to your plate.

Sparkling Lemon Water

A refreshing drink cuts through the richness and resets your palate.

Peach Iced Tea

Sweet and chilled, peach tea offers a Southern twist that plays off the spices in the chicken.

Want More Pasta Ideas with a Southern Twist?

If this Cajun Chicken Spaghetti in Creamy Garlic Mozzarella Sauce has you craving more bold flavors, we’ve got plenty of pasta recipes that go beyond the basics:

• Try the ultra-comforting Creamy Beef and Shells Recipe for a hearty weeknight meal.
• Looking for a fast stovetop favorite? The Stovetop Creamy Ground Beef Pasta hits the spot.
• The Creamy Ground Beef Alfredo Pasta brings a restaurant-style richness in under 30 minutes.
• Don’t miss our baked version with a twist—the Cheesy Baked Tortellini with Meat Sauce is bubbling comfort food.
• Or for a meaty spin, the Cheesesteak Tortellini in Rich Provolone Sauce is a savory dream.

Save This Recipe For Later

📌 Save this recipe to your Pinterest dinner board so you can come back to it any time.

And let me know in the comments how yours turned out. Did you make it spicier? Swap in shrimp or sausage? Try it with penne instead of spaghetti?

I love hearing how others make these recipes their own. Questions are welcome too—let’s help each other cook smarter.

Explore beautifully curated Southern-inspired meals on Mia Recipes on Pinterest and discover your new favorite weeknight dinner ideas!

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