Cheesy Penne and Cajun Chicken in Garlic Parmesan Cream

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When a cozy pasta night calls, nothing satisfies quite like a bowl of Cheesy Penne and Cajun Chicken in Garlic Parmesan Cream. This dish is a flavor-packed fusion of creamy, cheesy comfort and bold Cajun spice. Imagine tender penne pasta drenched in a rich Parmesan cream sauce, topped with golden Cajun-seasoned chicken that sizzles with smoky heat.

This recipe brings together indulgence and warmth in one skillet. The Cajun seasoning wakes up the palate, while the creamy sauce mellows the spice into pure harmony. It’s perfect for weeknights when you want something a little more exciting, yet still effortless to prepare.

Why You’ll Love This Cheesy Penne and Cajun Chicken

If you’re a fan of pasta dishes that walk the line between comfort and excitement, this one is calling your name. The pasta is perfectly al dente, the sauce is luxuriously creamy without being too heavy, and the chicken is seasoned just right to add depth without overpowering.

You’ll love how quickly it comes together with pantry staples, and how easily it can be customized. Want to toss in spinach or mushrooms? Go for it. Craving shrimp instead of chicken? It still works beautifully.

What Kind of Cajun Seasoning Should I Use?

For this recipe, you can use a store-bought Cajun seasoning blend or whip up your own with paprika, cayenne, garlic powder, onion powder, oregano, and a hint of thyme. Make sure to taste as you go, since different blends have varying salt levels and heat intensity.

The key is balance: you want that signature Cajun kick, but not so much that it overpowers the garlic Parmesan cream. A moderate blend works best, allowing the creamy sauce to shine while giving just the right amount of smoky heat.

Ingredients for the Cheesy Penne and Cajun Chicken in Garlic Parmesan Cream

Every ingredient in this recipe has a role to play in building layers of flavor and comfort. While the ingredient list is straightforward, the way they work together is what makes this dish so satisfying. From the pasta base to the seasoned chicken and silky sauce, each component enhances the next.

• Penne pasta: Holds sauce beautifully with its ridges and tube shape, making every bite creamy and cheesy.
• Chicken breast: Sliced thin and seasoned for the perfect protein topping that brings spicy balance to the rich sauce.
• Cajun seasoning: Adds bold, smoky flavor and a gentle heat that cuts through the creaminess.
• Butter: Used for sautéing the chicken and starting the roux for the sauce base.
• Garlic: Freshly minced garlic infuses the cream with deep flavor.
• Heavy cream: Creates that rich, velvety sauce texture we all crave in creamy pasta dishes.
• Parmesan cheese: Sharp and salty, it melts into the sauce giving it its cheesy backbone.
• Mozzarella cheese: Gives the dish its stretchy, gooey cheesy factor.
• Salt and black pepper: Simple yet essential for seasoning both the chicken and the sauce.

How To Make the Cheesy Penne and Cajun Chicken in Garlic Parmesan Cream

Step 1: Cook the Pasta

Bring a large pot of salted water to a boil. Cook the penne pasta according to package directions until al dente. Drain and set aside.

Step 2: Sear the Chicken

Season the sliced chicken breast with Cajun seasoning. In a large skillet, melt butter over medium heat. Add the chicken and cook until golden and cooked through. Remove and set aside.

Step 3: Make the Garlic Parmesan Sauce

In the same skillet, add more butter if needed and sauté the minced garlic until fragrant. Pour in the heavy cream and let it simmer for a few minutes. Stir in the Parmesan cheese until fully melted and smooth. Season with salt and black pepper.

Step 4: Combine Pasta and Sauce

Add the cooked penne to the skillet and stir to coat with the creamy garlic Parmesan sauce. Toss in the mozzarella and let it melt into the pasta.

Step 5: Add the Chicken

Return the Cajun chicken to the skillet, nestling it into the pasta. Give everything a gentle mix to blend flavors.

Step 6: Serve Hot

Serve immediately while the cheese is hot and melty. You can garnish with extra Parmesan or a sprinkle of Cajun spice if desired.

How to Serve and Store Cheesy Penne and Cajun Chicken in Garlic Parmesan Cream

This recipe is generous and satisfying, comfortably feeding four people with hearty portions. It’s perfect as a standalone meal, especially for cozy nights in when all you want is a hot, creamy bowl of something delicious. If you’re making it for a gathering or meal prep, it doubles easily.

To store, let the dish cool completely before transferring to an airtight container. It keeps well in the refrigerator for up to 3 days. When reheating, add a splash of milk or cream to restore the sauce’s creaminess. A gentle warm-up on the stove is ideal to preserve the texture of both pasta and chicken.

What to Serve With Cheesy Penne and Cajun Chicken?

Garlic Bread

Warm, buttery garlic bread is the ultimate companion for soaking up every last bit of that luscious sauce.

Steamed Broccoli

A simple side of vibrant green broccoli balances the richness with fresh flavor and crunch.

Caesar Salad

The crisp romaine, creamy dressing, and crunchy croutons add texture and freshness to your plate.

Roasted Brussels Sprouts

Slightly charred and nutty, they make a flavorful contrast to the creamy pasta.

Sweet Corn on the Cob

Naturally sweet and juicy, corn offers a summer-friendly, hands-on side that’s fun to eat.

Caprese Salad

Tomatoes, basil, and fresh mozzarella dressed in balsamic glaze brighten up the meal with tangy notes.

Sautéed Spinach

A light and fast side that wilts perfectly and complements the richness of the dish.

Lemon Iced Tea

Cool and slightly tart, it’s a refreshing sip between bites of creamy pasta and spiced chicken.

Want More Chicken Pasta Ideas?

If you loved this Cheesy Penne and Cajun Chicken in Garlic Parmesan Cream, you might want to try some of our other saucy, cheesy chicken creations:

• Creamy Ground Beef Alfredo Pasta for a savory twist on Alfredo classics.

• Cheesy Baked Tortellini with Meat Sauce is baked comfort at its cheesiest.

• Stovetop Creamy Ground Beef Pasta when you need a fast, flavorful one-pan dinner.

• Cheesesteak Tortellini in Rich Provolone Sauce if you’re in the mood for cheesy, meaty indulgence.

• Creamy Beef and Shells Recipe for a family-friendly, nostalgic pasta night.

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And let me know in the comments how yours turned out. Did you use homemade Cajun seasoning or a store blend? Did you sneak in veggies?

I love hearing how others make these recipes their own. Share your tips, swaps, or questions—let’s help each other cook smarter.

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