Creamy Cajun Beef Spaghetti with Three-Cheese Parmesan Sauce

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If you’re craving a dish that delivers bold flavors and ultimate comfort, this Creamy Cajun Beef Spaghetti with Three-Cheese Parmesan Sauce is exactly what you need. This hearty pasta recipe brings together smoky Cajun spice, tender ground beef, and a luscious, cheesy sauce that will have everyone asking for seconds.

What makes this recipe special is the combination of creamy richness with just the right kick of Cajun seasoning. The trio of cheeses in the Parmesan sauce — creamy mozzarella, sharp cheddar, and nutty parmesan — melt perfectly into the sauce, coating each strand of spaghetti with irresistible flavor.

Why You’ll Love This Creamy Cajun Beef Spaghetti

You’ll love this recipe for its quick preparation and crowd-pleasing results. It’s perfect for weeknight dinners yet impressive enough to serve at a casual dinner party. The spicy, cheesy sauce clings beautifully to the spaghetti, making each bite a burst of flavor and comfort. Plus, it’s a great way to jazz up ground beef into something extraordinary.

What Kind of Cajun Seasoning Should I Use?

You can use any store-bought Cajun seasoning blend, but if you like to control the salt and heat, making your own is a great idea. A homemade mix of paprika, garlic powder, onion powder, cayenne, thyme, oregano, salt, and pepper allows you to adjust the spice level to your preference. Whichever you choose, just be sure to taste and adjust as you go to keep the balance of creamy and spicy just right.

Ingredients for the Creamy Cajun Beef Spaghetti

This dish calls for simple ingredients you can find in any pantry or local store. Each one adds its own magic to the final flavor and texture.

• Spaghetti: The classic pasta base that holds the creamy, spicy sauce.
• Ground beef: Brings a savory, hearty depth and protein.
• Olive oil: Used to sauté the beef and aromatics, adding richness.
• Onion: Adds a sweet and savory aromatic flavor to the dish.
• Garlic: Gives the sauce a robust, savory kick.
• Cajun seasoning: The star spice blend that brings heat and smoky flavor.
• Heavy cream: Makes the sauce creamy and indulgent.
• Mozzarella cheese: Melts beautifully into the sauce for a smooth texture.
• Cheddar cheese: Adds sharpness and depth of flavor.
• Parmesan cheese: Finishes the sauce with nutty, salty notes.
• Salt & pepper: Essential for balancing all the flavors.
• Fresh parsley: For garnish and a hint of freshness.

How To Make the Creamy Cajun Beef Spaghetti

Step 1: Cook the Spaghetti

Bring a large pot of salted water to a boil and cook the spaghetti according to package directions until al dente. Drain and set aside.

Step 2: Brown the Beef

Heat olive oil in a large skillet over medium heat. Add the ground beef, breaking it up with a spoon. Cook until browned and no longer pink. Remove and set aside.

Step 3: Sauté the Aromatics

In the same skillet, add chopped onion and minced garlic. Sauté until the onion is translucent and fragrant.

Step 4: Add the Spice and Cream

Sprinkle Cajun seasoning over the onions and garlic, stirring well. Pour in the heavy cream and bring to a gentle simmer.

Step 5: Melt the Cheeses

Reduce heat to low. Stir in mozzarella, cheddar, and parmesan cheeses one at a time, allowing each to melt before adding the next.

Step 6: Combine and Serve

Return the cooked beef to the skillet and stir into the sauce. Add the cooked spaghetti and toss everything together until the pasta is fully coated. Garnish with fresh parsley and serve warm.

How to Serve and Store Creamy Cajun Beef Spaghetti

This dish is hearty enough to feed about 4 to 6 people, making it perfect for family dinners or small gatherings. Serve it straight from the skillet for a rustic, cozy feel, or plate it up with a sprinkle of extra parmesan and fresh parsley for a more polished presentation. Any leftovers can be stored in an airtight container in the refrigerator for up to 3 days. Reheat gently on the stovetop or in the microwave with a splash of cream to maintain its creamy texture.

What to Serve With Creamy Cajun Beef Spaghetti?

Garlic Bread

Warm, buttery garlic bread pairs beautifully with the creamy, spicy sauce.

Simple Green Salad

A fresh salad with a light vinaigrette balances the richness of the pasta.

Roasted Vegetables

Try roasted broccoli, zucchini, or asparagus for a healthy side.

Southern-Style Cornbread

For a hearty and slightly sweet twist, cornbread is a great companion.

Crispy Brussels Sprouts

The crunch of roasted Brussels sprouts adds great texture alongside the creamy pasta.

Parmesan Roasted Potatoes

Golden, crispy potatoes with parmesan complement the cheesy sauce.

Lemon Butter Shrimp

For a surf-and-turf experience, serve a few lemon butter shrimp on the side.

Want More Comforting Pasta Ideas?

If you enjoyed this creamy Cajun beef spaghetti, you might love these other indulgent pasta creations:

• Creamy Beef and Shells Recipe for a quick, cheesy weeknight fix.
• Stovetop Creamy Ground Beef Pasta that’s as simple as it is delicious.
• Cheesesteak Tortellini in Rich Provolone Sauce for a fun twist on two classics.
• Creamy Ground Beef Alfredo Pasta when you’re craving something ultra creamy and comforting.
• One-Pot Smoked Sausage Pasta for a smoky, one-dish wonder.

Save This Recipe For Later

📌 Save this recipe to your Pinterest dinner board so you can come back to it any time.

And let me know in the comments how yours turned out. Did you add extra Cajun spice or tone it down? Maybe you sprinkled in more cheese?

I love hearing how others make these recipes their own. Questions are welcome too — let’s help each other cook smarter.

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