When you want something indulgent and packed with bold flavor, Creamy Cajun Chicken Fettuccine with Garlic Mozzarella Cheese Sauce is exactly what your dinner plate needs. This dish wraps tender, spiced chicken in silky ribbons of fettuccine, then bathes everything in a luscious garlic-infused mozzarella cream sauce that’s impossible to resist.

It’s one of those meals that feels like a restaurant special, but it comes together easily in your own kitchen. The Cajun seasoning gives the chicken a smoky kick, while the cheese sauce balances the heat with richness and depth. Whether it’s a cozy night in or a casual dinner party, this fettuccine promises to satisfy every craving.

Why You’ll Love This Creamy Cajun Chicken Fettuccine

This dish brings together the best of all worlds: bold flavor, creamy comfort, and simple ingredients. The mozzarella sauce is smooth and savory, with a gentle garlicky punch that pairs beautifully with the spice of Cajun chicken. It’s hearty without being heavy, and just fancy enough to serve to guests without fuss.

The texture of the fettuccine catches every bit of sauce, making each bite a creamy, spicy, satisfying forkful. It’s also versatile enough to tweak—add shrimp, swap pasta shapes, or toss in some sun-dried tomatoes for a tangy twist.

What Kind of Fettuccine Should I Use?

Classic fettuccine is the ideal choice for this dish because of its flat, wide shape. It holds the garlic mozzarella cheese sauce perfectly and gives a nice balance to the sliced Cajun chicken. You can use fresh pasta if you’re aiming for that extra-soft bite, or dried fettuccine for a more traditional al dente texture. Either way, cook it just until tender and let it soak up every last drop of that creamy sauce.

Ingredients for the Creamy Cajun Chicken Fettuccine

To create this unforgettable meal, you’ll need a mix of spices, dairy, and pantry staples. The Cajun seasoning adds that signature Southern heat, while the garlic mozzarella cheese sauce brings velvety, cheesy richness that clings to every fettuccine strand.

Fettuccine pasta
Chicken breasts
Cajun seasoning
Olive oil
Salted butter
Garlic cloves
All-purpose flour
Whole milk
Heavy cream
Mozzarella cheese
Parmesan cheese
Fresh parsley

Each ingredient plays a crucial role. Chicken breasts offer lean protein and absorb the Cajun spice beautifully. Cajun seasoning delivers bold, zesty flavor. Garlic builds that savory base, while mozzarella and Parmesan cheeses melt into a creamy, indulgent sauce. And don’t skip the butter and cream — they’re essential for richness.

Creamy Cajun Chicken Fettuccine with Garlic Mozzarella Cheese Sauce 2

How To Make the Creamy Cajun Chicken Fettuccine

Step 1: Cook the Pasta

Bring a large pot of salted water to a boil and cook the fettuccine according to the package directions. Drain and set aside, reserving about 1/2 cup of pasta water.

Step 2: Season and Sear the Chicken

Pat the chicken breasts dry, then coat them generously with Cajun seasoning. In a large skillet over medium-high heat, add olive oil and sear the chicken until golden brown and fully cooked through, about 5 to 6 minutes per side. Let rest, then slice into strips.

Step 3: Make the Garlic Mozzarella Sauce

In the same skillet, melt butter and sauté minced garlic until fragrant. Sprinkle in flour and whisk to make a roux. Slowly pour in milk and heavy cream, whisking constantly until smooth. Reduce the heat and stir in mozzarella and Parmesan until fully melted and creamy.

Step 4: Combine Everything

Add the cooked fettuccine to the sauce, tossing to coat. If needed, use the reserved pasta water to loosen the sauce. Nestle the sliced Cajun chicken on top, garnish with fresh parsley, and serve hot.

Serving and Storing Creamy Cajun Chicken Fettuccine

This dish is rich enough to be a meal on its own and serves about 4 people generously. If you’re cooking for two, you’ll have delicious leftovers that reheat beautifully. Store any extra fettuccine in an airtight container in the refrigerator for up to 3 days. To reheat, add a splash of milk or cream in a saucepan over low heat and stir until the sauce regains its smooth texture.

Avoid freezing this dish, as the cream-based sauce can separate. But if you must freeze, freeze the chicken separately from the pasta and sauce for best results.

What to Serve With Creamy Cajun Chicken Fettuccine?

Garlic Bread with Herbs

Crispy, buttery garlic bread is a no-brainer. It helps scoop up the cheesy sauce and complements the garlicky flavors in the dish.

Roasted Broccoli

The slight bitterness of roasted broccoli cuts through the richness and brings a welcome green crunch to the plate.

Caesar Salad

Crisp romaine, Parmesan shavings, and creamy Caesar dressing balance the heat of the Cajun chicken.

Grilled Asparagus

A light char and natural sweetness from asparagus offer a nice contrast to the creamy sauce.

Cornbread Muffins

For a Southern-inspired side, serve soft cornbread muffins that echo the Cajun roots of the dish.

Sautéed Mushrooms

Mushrooms bring earthiness and a meaty texture that work beautifully with the creamy sauce.

Lemon Butter Green Beans

The citrusy pop of lemon butter brightens each bite, keeping your palate refreshed.

Tomato Basil Salad

Cool and tangy, this fresh salad adds acidity and pairs especially well if you spice up your Cajun seasoning.

Want More Pasta Dinner Ideas?

If you’re a fan of creamy, comforting pasta dinners like this one, don’t miss these flavorful recipes that bring bold twists to the table:

Creamy Beef and Shells Recipe for a nostalgic, hearty dish the whole family will love.
Stovetop Creamy Ground Beef Pasta for a quick weeknight meal that never fails.
Cheesesteak Tortellini in Rich Provolone Sauce if you’re craving cheesy indulgence with a Philly twist.
Creamy Ground Beef Alfredo Pasta to double down on the richness.
One Pot Smoked Sausage Pasta when you want maximum flavor with minimal cleanup.

Save This Recipe For Later

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And let me know in the comments how yours turned out. Did you go spicy with extra Cajun? Did you sneak in some shrimp or mushrooms?

I love hearing how you make these recipes your own. Questions are welcome too — let’s make dinner easier together.

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