This Creamy Cajun Chicken Penne Pasta with Garlic Mozzarella Sauce is the kind of dish that brings pure comfort to your table with a spicy kick. Juicy chicken breasts are seasoned with bold Cajun spices, seared to perfection, then tossed with penne pasta in a silky mozzarella and garlic cream sauce that’s rich and irresistible.

Every bite is bursting with a warm heat that blends beautifully with the creaminess of the sauce, creating a harmony of flavors that feels like a restaurant-quality meal made right at home. Whether you’re planning a weeknight dinner or entertaining guests, this pasta is a crowd-pleaser that delivers both ease and indulgence.

Why You’ll Love This Creamy Cajun Chicken Penne Pasta

If you enjoy meals that feel both cozy and exciting, this pasta will win you over fast. The Cajun seasoning gives the dish a vibrant, smoky depth, while the cream and cheese add lushness without being heavy. It’s quick to make, easy to customize with veggies or seafood, and tastes even better the next day.

Plus, the mozzarella garlic sauce is like a grown-up version of mac and cheese, infused with just enough garlic to be addicting without overpowering.

What Kind of Cajun Seasoning Should I Use?

You can use any store-bought Cajun blend you like, but for the best flavor, look for one with a good balance of paprika, garlic, onion, thyme, and cayenne. Some are saltier than others, so taste as you go. If you like it smoky, choose one with smoked paprika. For a homemade option, mix paprika, garlic powder, onion powder, cayenne, black pepper, oregano, thyme, and a pinch of salt. This way, you control the heat and salt levels perfectly.

Ingredients for the Creamy Cajun Chicken Penne Pasta

To make this delicious pasta dish come to life, you need a mix of pantry staples and a few fresh ingredients. Each one adds a layer of flavor, texture, or richness that builds the whole experience. Having everything prepped and ready before cooking makes it go smoother and ensures that nothing gets missed.

Chicken breasts – These provide the protein and soak up the Cajun seasoning beautifully.
Penne pasta – Ideal for catching all that creamy sauce in its ridges.
Cajun seasoning – The star of the show, giving the dish that spicy, bold flair.
Olive oil – Used for searing the chicken and adding a silky touch.
Garlic – Fresh minced garlic adds depth and that classic Italian warmth.
Heavy cream – This makes the sauce rich, velvety, and indulgent.
Mozzarella cheese – Melts smoothly into the sauce, adding mild, creamy flavor.
Parmesan cheese – Gives a salty, sharp edge to balance the creaminess.
Butter – Helps to bring everything together and adds a glossy finish.
Salt & pepper – Essential for adjusting the flavor to your liking.
Fresh parsley (optional) – A sprinkle on top gives freshness and color.

How To Make the Creamy Cajun Chicken Penne Pasta

Step 1: Season and Sear the Chicken

Coat the chicken breasts generously with Cajun seasoning on both sides. Heat olive oil in a large skillet over medium heat. Sear the chicken for about 5-6 minutes per side until golden brown and fully cooked. Remove from the skillet and let it rest.

Step 2: Cook the Pasta

While the chicken cooks, bring a large pot of salted water to a boil and cook the penne pasta according to package directions. Drain and set aside.

Step 3: Make the Garlic Mozzarella Sauce

In the same skillet, lower the heat and add butter. Stir in the minced garlic and cook until fragrant. Pour in the heavy cream and let it simmer gently. Stir in the mozzarella and Parmesan cheeses until smooth and melted.

Step 4: Combine Everything

Slice the cooked chicken into strips. Add the pasta into the skillet with the sauce and toss to coat. Place the chicken on top and stir gently to combine. Season with salt and pepper to taste.

Step 5: Serve It Up

Plate the pasta, garnish with chopped fresh parsley if using, and serve hot. Get ready for creamy, Cajun-spiced bliss!

Serving and Storing Creamy Cajun Chicken Penne Pasta

This Creamy Cajun Chicken Penne Pasta serves about four generous portions, making it perfect for a hearty dinner or meal prepping for the week. Serve it immediately while the sauce is hot and creamy, right after tossing the chicken and pasta together. The mozzarella garlic sauce thickens as it cools, so if you’re reheating, add a splash of milk or cream to revive the smooth texture.

To store leftovers, transfer them to an airtight container and refrigerate for up to 4 days. Reheat on the stovetop or in the microwave with a bit of extra cream or water to bring back the original creaminess. It’s not ideal for freezing due to the dairy, which may separate, but it’s too tasty to last that long anyway.

What to Serve With Creamy Cajun Chicken Penne Pasta?

Garlic Bread

You can never go wrong with warm garlic bread. It’s perfect for scooping up the extra sauce left on your plate.

Caesar Salad

A crisp Caesar salad adds a cool contrast and a refreshing crunch that balances out the richness of the pasta.

Roasted Broccoli

Lightly seasoned and oven-roasted, broccoli offers a healthy and flavorful veggie side that holds up to the bold Cajun flavors.

Sauteed Spinach with Garlic

A simple garlicky spinach dish complements the creamy texture and keeps things light.

Cornbread Muffins

Soft and slightly sweet cornbread muffins create a cozy Southern vibe next to the spicy chicken.

Grilled Zucchini

Grilling brings out a natural sweetness in zucchini that pairs nicely with the smoky Cajun spice.

Classic Coleslaw

For a little crunch and tang, serve up a scoop of creamy coleslaw to cut through the richness.

Sweet Tea or Lemonade

These drinks bring Southern charm to the meal and cool down the heat from the seasoning.

Want More Pasta Ideas with a Twist?

If you love this Creamy Cajun Chicken Penne Pasta, don’t miss out on these other crave-worthy dishes that bring creamy sauces and bold flavors to the table:

• Creamy Beef and Shells Recipe for a meaty pasta that’s as comforting as it is rich.
• Stovetop Creamy Ground Beef Pasta when you want something quick and saucy.
• Cheesesteak Tortellini in Rich Provolone Sauce for a Philly-inspired twist.
• Creamy Ground Beef Alfredo Pasta for a satisfying weeknight dinner.
• One Pot Smoked Sausage Pasta when you’re craving something smoky and hearty.

Save This Recipe For Later

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And let me know in the comments how yours turned out. Did you stick with penne or try another pasta? Did you toss in shrimp or go extra heavy on the garlic?

I love hearing how others make these recipes their own. Questions are welcome too — let’s help each other cook with more flavor.

Explore beautifully curated health-boosting dinners and savory pasta favorites on Mia Recipes on Pinterest and discover your new weeknight go-to.