Creamy Cajun Chicken Rotini with Garlic Mozzarella Sauce is the kind of dinner that checks all the boxes: rich, spicy, cheesy, and incredibly satisfying. If you’re craving bold flavor but want something comforting and creamy, this is your recipe. It’s a one-pan wonder that brings together tender rotini, juicy Cajun-seasoned chicken, and a dreamy garlic mozzarella sauce that coats every bite.

The creamy garlic base balances the spicy Cajun seasoning perfectly, creating a sauce that’s luscious without being too heavy. It’s a great option for both weeknight meals and casual entertaining because it’s quick to make but tastes like something you’d order at a restaurant. A final touch of melty mozzarella seals the deal and makes this a pasta dish worth repeating.

Why You’ll Love This Creamy Cajun Chicken Rotini

This dish has that irresistible quality where every bite makes you go back for more. The Cajun spice gives it depth and a little heat, while the mozzarella garlic sauce makes it indulgent without going overboard. It’s quick, easy, and comforting — a meal that feeds a hungry family or impresses dinner guests. The rotini is the perfect pasta for capturing the sauce in every curve, giving you a flavorful bite every time.

What Kind of Rotini or Pasta Should I Use?

Rotini works wonders in this recipe because its spiral shape holds onto the creamy sauce like a charm. However, if you’re out of rotini, penne, fusilli, or even farfalle can work beautifully. The key is to pick a short, ridged pasta that won’t disappear under the sauce and complements the chicken bites. Avoid long, delicate noodles like spaghetti or fettuccine—they don’t offer the same satisfying texture with the hearty sauce.

Ingredients for the Creamy Cajun Chicken Rotini

The ingredient list for this dish is straightforward and made with pantry staples. Each item has its own role, building layers of flavor and texture that come together into one creamy, spicy, savory masterpiece.

Rotini pasta
Boneless, skinless chicken breasts
Cajun seasoning
Olive oil
Butter
Garlic cloves
Heavy cream
Chicken broth
Mozzarella cheese
Parmesan cheese
Salt
Black pepper

How To Make the Creamy Cajun Chicken Rotini

Step 1: Cook the Rotini

Bring a large pot of salted water to a boil and cook the rotini until al dente. Drain and set aside.

Step 2: Season and Cook the Chicken

Cut the chicken into bite-sized pieces and toss them with Cajun seasoning until well-coated. Heat olive oil in a large skillet over medium-high heat, then add the chicken. Sear until golden and fully cooked, then remove and set aside.

Step 3: Make the Garlic Mozzarella Sauce

In the same skillet, melt butter and sauté minced garlic until fragrant. Add heavy cream and chicken broth, stirring well. Bring to a gentle simmer.

Step 4: Add Cheeses

Lower the heat and stir in mozzarella and Parmesan until melted and smooth. Season with salt and black pepper to taste.

Step 5: Combine and Serve

Add the cooked rotini and chicken back into the skillet. Toss everything together to coat in the sauce. Let it simmer for a couple of minutes to absorb the flavors, then serve hot with extra cheese if you like.

Watch Out for These Mistakes While Cooking

One of the most common mistakes with this dish is overcooking the chicken. Cajun seasoning has a tendency to blacken quickly, which can make it seem done before the inside is cooked through. Keep your heat at medium-high and monitor the chicken closely.

Another issue is using pre-shredded mozzarella, which often contains anti-caking agents that prevent it from melting smoothly. For the creamiest sauce, shred your own mozzarella.

Finally, don’t rush the simmering step. Letting the pasta and chicken soak in the sauce for a couple of minutes lets everything meld together beautifully.

Serving and Storing Creamy Cajun Chicken Rotini

This pasta is best served hot right from the skillet, when the sauce is silky and the cheese is perfectly melted. It feeds about 4 people generously, or up to 6 if served with a side.

Store leftovers in an airtight container in the fridge for up to 3 days. To reheat, add a splash of cream or milk and warm it over low heat to bring the sauce back to life.

What to Serve With Creamy Cajun Chicken Rotini?

Garlic Bread

A slice of crusty garlic bread is the perfect way to scoop up that extra sauce.

Simple Caesar Salad

The crisp romaine and creamy dressing add a cool contrast to the spicy pasta.

Roasted Broccoli

Its mild bitterness balances the richness of the sauce.

Sauteed Spinach

Quick and healthy, it adds a pop of green without stealing the spotlight.

Grilled Corn on the Cob

A sweet, smoky side that plays well with Cajun spice.

Baked Zucchini Rounds

Light and crispy, they bring in a nice texture contrast.

Sparkling Lemon Water

A fresh and fizzy drink to cleanse the palate between bites.

Parmesan Crusted Asparagus

A cheesy and crunchy veggie side that feels just as indulgent as the main dish.

Want More Pasta Ideas?

If you love this Creamy Cajun Chicken Rotini, there are plenty more pasta creations waiting to win you over. Try these next:

Creamy Garlic Butter Chicken Rotini in Parmesan Sauce if you’re craving garlic-forward comfort with a twist.
Creamy Tuscan Sausage Pasta for a bold and herbaceous experience.
Cheese Shrimp Penne Pasta with Spinach if you want to switch it up with seafood.
Marry Me Chicken Pasta for creamy richness and romantic vibes.
One-Pot Creamy Beef and Garlic Butter Pasta when you need a comforting beefy classic.

Creamy Cajun Chicken Rotini with Garlic Mozzarella Sauce 2

Save This Recipe For Later

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And let me know in the comments how yours turned out. Did you make it spicier or add mushrooms? Maybe a handful of spinach or sun-dried tomatoes?

I love hearing how others make these recipes their own. Questions are welcome too — let’s help each other cook smarter.

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Conclusion

Creamy Cajun Chicken Rotini with Garlic Mozzarella Sauce is one of those rare pasta recipes that hits every note just right. It’s bold and spicy, but perfectly creamy and satisfying. Whether it’s a cozy weeknight or a casual gathering, this dish is always a hit. With simple ingredients and big flavor, it’s a recipe worth saving, sharing, and definitely repeating.