Creamy Cajun Chicken Rotini with Mozzarella Alfredo Sauce

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Get ready to meet your new favorite comfort food: creamy Cajun chicken rotini with mozzarella Alfredo sauce. This dish brings together the bold, spicy warmth of Cajun seasoning with the silky indulgence of Alfredo sauce, all wrapped up in tender spirals of rotini pasta. It’s the kind of meal that hugs you from the inside out.

Imagine juicy, seasoned chicken breasts seared until golden and then simmered in a rich, cheesy Alfredo sauce infused with a touch of Cajun heat. The mozzarella melts into every swirl of pasta, coating each bite in creamy, dreamy deliciousness. Whether you’re cooking for a cozy family dinner or want something crowd-pleasing for guests, this one checks all the boxes.

Why You’ll Love This Creamy Cajun Chicken Rotini with Mozzarella Alfredo Sauce

It combines spicy and creamy in the most addictive way. The Cajun seasoning gives the dish its signature kick, but the mellow mozzarella Alfredo balances it out so beautifully. It’s a full-flavored experience without overwhelming heat, perfect for those who like a little spice but still crave comfort.

Plus, it’s easy to make in one pan and doesn’t require any fancy ingredients. Just pantry staples, fresh chicken, and a love of good food. It’s a weeknight win that tastes like a weekend indulgence.

What Kind of Chicken Should I Use?

Boneless, skinless chicken breasts are the most convenient choice here. They cook quickly and slice easily into the rotini without overpowering the dish. You could also use chicken thighs if you prefer something even more juicy and flavorful.

If you’re short on time, leftover cooked chicken or even a rotisserie chicken can absolutely work in a pinch. Just slice or shred it and stir it into the sauce toward the end to warm through without overcooking.

Ingredients for the Creamy Cajun Chicken Rotini with Mozzarella Alfredo Sauce

This dish is all about bold flavors and creamy textures, so each ingredient plays a key role in creating the magic. You likely already have most of these on hand, and if not, they’re easy to find at any grocery store. Here’s what you’ll need:

• Rotini pasta
• Boneless, skinless chicken breasts
• Cajun seasoning
• Olive oil
• Garlic cloves
• Butter
• Heavy cream
• Mozzarella cheese
• Parmesan cheese
• Salt and pepper
• Fresh parsley

The rotini gives a perfect twisty texture that holds the sauce beautifully. The chicken brings hearty protein and pairs well with the spice. Cajun seasoning wakes everything up with bold, warm flavors, while the mozzarella and Parmesan melt into a velvety sauce. Butter and heavy cream create that classic Alfredo richness, and garlic deepens the overall flavor.

How To Make the Creamy Cajun Chicken Rotini with Mozzarella Alfredo Sauce

Step 1: Season and Sear the Chicken

Start by seasoning your chicken breasts generously with Cajun seasoning, salt, and pepper. Heat olive oil in a skillet over medium-high heat and sear the chicken for 5–7 minutes per side until golden and cooked through. Remove and let rest before slicing.

Step 2: Boil the Rotini

While the chicken is cooking, bring a large pot of salted water to a boil. Add the rotini and cook according to package directions until al dente. Drain and set aside.

Step 3: Make the Alfredo Sauce

In the same skillet used for the chicken, lower the heat to medium and add butter and minced garlic. Sauté until fragrant, then pour in the heavy cream. Stir constantly, letting it simmer gently for about 3–5 minutes.

Step 4: Add the Cheese

Once the cream has thickened slightly, add shredded mozzarella and grated Parmesan. Stir until both cheeses melt completely into a smooth, velvety sauce.

Step 5: Bring It All Together

Slice the chicken and return it to the pan. Add in the cooked rotini and toss everything together until evenly coated in the creamy sauce.

Step 6: Garnish and Serve

Top with a sprinkle of fresh parsley for color and freshness. Serve immediately while everything is hot and creamy.

How to Serve and Store Creamy Cajun Chicken Rotini with Mozzarella Alfredo Sauce

This creamy Cajun chicken rotini serves up beautifully hot and fresh, right off the stove. The sauce is at its dreamiest when warm, clinging to the curls of pasta and the juicy slices of chicken. You can serve it directly from the pan, or plate it up with a sprinkle of fresh parsley and extra Parmesan if you’re feeling fancy.

This recipe makes enough for 4 hearty portions, making it perfect for family dinner or meal prep. If you do have leftovers, store them in an airtight container in the fridge for up to 3 days. When reheating, add a splash of cream or milk to loosen up the sauce and keep it creamy.

Avoid freezing if you can—the cheese sauce may separate and lose its luscious texture.

What to Serve With Creamy Cajun Chicken Rotini?

Garlic Bread

You can never go wrong with crusty garlic bread. It’s perfect for scooping up any leftover sauce.

Caesar Salad

A chilled Caesar salad with crisp romaine, Parmesan, and crunchy croutons balances the richness of the pasta.

Roasted Vegetables

Try a tray of roasted broccoli, carrots, or asparagus to bring color and a healthy crunch.

Corn on the Cob

A slightly sweet, buttery cob of corn makes a fun Southern-style side.

Fried Green Tomatoes

These crispy bites add a tart contrast and a little Southern flair.

Sauteed Spinach

Lightly sauteed spinach with garlic is a quick, nutrient-rich addition.

Sweet Tea or Lemonade

For drinks, pair it with something refreshing and Southern-inspired to complete the vibe.

Pickled Okra or Jalapenos

If you like extra tang and heat, a few pickled sides can really punch up the plate.

Want More Pasta Ideas with a Kick?

If you loved this creamy Cajun chicken rotini, you’ll want to try some of these flavor-packed pasta dishes that bring big comfort and bold taste:

• Try the Creamy Beef and Shells Recipe for a nostalgic dish that blends savory beef and rich sauce.
• The Stovetop Creamy Ground Beef Pasta is another one-pan wonder with hearty flavor.
• For a cheesy twist, check out Cheesesteak Tortellini in Rich Provolone Sauce that’s loaded with gooey indulgence.
• Looking for something smoky? One Pot Smoked Sausage Pasta brings the flavor and simplicity in one satisfying meal.
• And don’t miss the Creamy Ground Beef Alfredo Pasta for a cozy dinner that’s ready in no time.

Save This Recipe For Later

📌 Save this recipe to your Pinterest dinner board so you can come back to it whenever that Cajun craving hits.

And let me know in the comments how it turned out for you. Did you go full Cajun heat or keep it mild? Did you throw in extra cheese? I’m always excited to hear your twists on this dish.

Explore beautifully curated creamy pastas and feel-good meals on Mia Recipes on Pinterest and discover your new weeknight favorite: Mia Recipes on Pinterest.

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