This Garlic Chicken Bites & Creamy Cajun Spinach Artichoke Alfredo Pasta is a flavor-packed dish that satisfies both your cravings and your appetite. Picture juicy, garlicky chicken bites paired with pasta drenched in a rich, cheesy Cajun Alfredo sauce, loaded with tender spinach and tangy artichokes. It’s a mouthful to say, but even better to taste.

The combination of creamy, spicy, and savory flavors wrapped into one comforting pasta bowl makes this recipe a standout. Whether you’re planning a cozy dinner for two or hosting family on a casual weeknight, this dish will absolutely hit the spot. Every bite delivers bold Cajun flair balanced with creaminess and just the right amount of heat.

Why You’ll Love This Garlic Chicken Bites & Creamy Cajun Spinach Artichoke Alfredo Pasta

This isn’t your average Alfredo pasta. The Cajun spices bring warmth and complexity, while the chicken bites add satisfying protein. The spinach and artichokes elevate the sauce with texture and nutrition, and the garlic? Well, it brings everything together with that unmistakable kick of flavor.

It’s an easy recipe that feels like a restaurant-style meal without the price tag. You can prep it in under an hour, and it reheats beautifully the next day.

What Kind of Chicken Should I Use?

Boneless, skinless chicken breasts are perfect here because they sear quickly and soak up all the garlicky goodness in the pan. You can also use chicken thighs if you prefer a juicier bite. Just be sure to cut them into even, bite-sized chunks so they cook evenly and stay tender.

Ingredients for the Garlic Chicken Bites & Creamy Cajun Spinach Artichoke Alfredo Pasta

This flavorful dish comes together with a mix of pantry staples and fresh ingredients. Here’s what you’ll need to make it rich, creamy, and perfectly seasoned:

Chicken breast
Olive oil
Minced garlic
Cajun seasoning
Pasta
Cream cheese
Heavy cream
Parmesan cheese
Spinach
Artichoke hearts
Salt & pepper

Each ingredient plays a part: Chicken breast adds protein and flavor, olive oil is used for sautéing, minced garlic gives aromatic depth, and Cajun seasoning brings a bold, zesty flavor. Pasta serves as the hearty base, while cream cheese and heavy cream create the luscious sauce. Parmesan adds a nutty richness, and spinach and artichokes give it texture, freshness, and complexity. A pinch of salt & pepper ties it all together.

Garlic Chicken Bites & Creamy Cajun Spinach Artichoke Alfredo Pasta 2

How To Make the Garlic Chicken Bites & Creamy Cajun Spinach Artichoke Alfredo Pasta

Step 1: Cook the Pasta

Boil a pot of salted water and cook your pasta until al dente. Drain and set aside, reserving about half a cup of the pasta water.

Step 2: Sear the Chicken

Season the chicken breast pieces with Cajun seasoning. Heat olive oil in a skillet, then add the chicken and sear until golden brown and fully cooked. Remove from the pan and keep warm.

Step 3: Sauté the Garlic

In the same skillet, add a little more olive oil if needed and sauté the minced garlic until fragrant, about 30 seconds.

Step 4: Make the Sauce

Add cream cheese and heavy cream to the skillet, stirring until smooth. Slowly mix in the Parmesan cheese. If the sauce gets too thick, add a splash of reserved pasta water.

Step 5: Add the Veggies

Toss in the spinach and chopped artichoke hearts. Let them simmer in the sauce until the spinach wilts and everything is well combined.

Step 6: Bring It Together

Return the cooked pasta and chicken to the skillet. Stir everything until coated and heated through. Adjust seasoning with salt and pepper.

Step 7: Serve

Serve immediately with extra Parmesan on top if you’d like. A little sprinkle of Cajun seasoning over the plate adds a nice final touch.

How to Serve and Store This Garlic Chicken Bites & Creamy Cajun Spinach Artichoke Alfredo Pasta

This creamy pasta dish is hearty enough to stand on its own, but it also pairs beautifully with crusty bread or a crisp green salad. It feeds about 4 to 6 people comfortably, making it great for family dinners or even meal prep.

If you have leftovers, store them in an airtight container in the fridge for up to 3 days. The sauce may thicken, so when reheating, stir in a splash of milk or cream to loosen it back up.

What to Serve With Garlic Chicken Bites & Creamy Cajun Spinach Artichoke Alfredo Pasta?

Garlic Bread with a Crunch

A side of toasted garlic bread is perfect for soaking up the extra creamy Alfredo sauce.

Simple Green Salad

Balance out the richness with a fresh salad tossed in a zesty vinaigrette.

Roasted Vegetables

Try roasted broccoli, asparagus, or bell peppers for added color and nutrition.

Creamy Coleslaw

A cool, tangy slaw can provide a refreshing contrast to the warm Cajun spice.

Bruschetta

A tomato and basil bruschetta brightens the meal with acidity and freshness.

Grilled Corn on the Cob

Corn with butter and a sprinkle of chili powder fits the Southern-Cajun flair.

Parmesan Breadsticks

Serve warm, cheesy breadsticks for a savory bite between pasta forkfuls.

Balsamic Roasted Mushrooms

Savory mushrooms roasted in balsamic vinegar and herbs complement the richness of the Alfredo.

Want More Pasta Ideas?

If you’re loving this creamy Cajun-inspired dish, you might want to explore other comforting pasta recipes too:

Creamy Beef and Shells Recipe for a meaty, family-style favorite.
Stovetop Creamy Ground Beef Pasta for quick weeknight comfort.
Creamy Ground Beef Alfredo Pasta if you crave more beefy Alfredo goodness.
Cheesesteak Tortellini in Rich Provolone Sauce for a decadent twist.
One-Pot Smoked Sausage Pasta when you want one skillet, zero hassle.

Save This Recipe For Later

📌 Save this recipe to your Pinterest dinner board so you can come back to it any time.

And let me know in the comments how yours turned out. Did you go heavier on the Cajun seasoning or keep it mild? Did you sneak in mushrooms or maybe sun-dried tomatoes?

I love hearing how others make these recipes their own. Questions are welcome too — let’s help each other cook better and eat well.

Explore beautifully curated health-boosting drinks and more easy family meals on Mia Recipes on Pinterest and find your next weeknight favorite.