When comfort food calls, this Cajun Garlic Butter Chicken Penne answers with bold flavor and indulgent texture. Juicy seasoned chicken is seared to golden perfection, then smothered in a silky, garlic butter sauce that packs just the right punch of Cajun heat. Tossed with tender penne pasta and finished with a creamy Parmesan sauce, it’s a dish that hits every craving note.

Whether you’re serving this for a cozy weeknight dinner or spicing up a weekend gathering, the layers of flavor in this pasta dish make it unforgettable. The savory Cajun spices, the richness of real butter, the sharp tang of Parmesan, and the comforting bite of pasta all come together in a one-pan meal that’s as satisfying as it is simple to make.

Why You’ll Love This Cajun Garlic Butter Chicken Penne

This dish is a spicy twist on a creamy pasta classic. It’s hearty enough to satisfy, but easy enough for any day of the week. The Cajun seasoning brings warmth without overpowering, and the Parmesan adds a rich umami flavor that pulls everything together. Plus, it’s ready in under an hour and makes fantastic leftovers.

If you’re looking for a dinner that feels like restaurant quality without leaving home, this one delivers. It’s also versatile—add some shrimp or mushrooms to make it your own.

What Kind of Chicken Should I Use?

Boneless, skinless chicken breasts are ideal for this recipe because they cook quickly and absorb flavor well. If you prefer dark meat, boneless thighs are a tasty alternative and stay juicy even with a longer cook time. Just make sure the chicken is cut into bite-size pieces for even searing and perfect pasta pairing.

Ingredients for the Cajun Garlic Butter Chicken Penne

This recipe uses simple pantry and fridge staples, but each one plays an important role in layering flavor and richness. From the bold seasoning to the creamy sauce, everything works together to create the perfect bite.

Chicken breast: Provides lean, protein-packed substance that soaks up the Cajun flavor.
Penne pasta: The shape holds onto the sauce beautifully and gives every bite a satisfying texture.
Butter: Adds indulgent richness and carries the garlic and Cajun spices.
Garlic cloves: Essential for that warm, aromatic depth that anchors the sauce.
Cajun seasoning: Brings smoky, spicy warmth that transforms the dish from basic to bold.
Heavy cream: Creates the luscious base for the Parmesan sauce.
Parmesan cheese: Adds salty, nutty complexity that thickens the sauce and balances the spice.
Olive oil: Helps sear the chicken and infuses a little Mediterranean flavor.
Salt and pepper: Simple essentials to season every layer.

Cajun Garlic Butter Chicken Penne in Creamy Parmesan Sauce 2

How To Make the Cajun Garlic Butter Chicken Penne

Step 1: Sear the Chicken

Heat olive oil in a large skillet over medium-high heat. Season the chicken with salt, pepper, and Cajun seasoning, then add to the hot pan. Cook until golden brown and cooked through. Transfer to a plate and set aside.

Step 2: Cook the Pasta

Boil a pot of salted water and cook the penne pasta until al dente. Drain and set aside, reserving about a cup of pasta water in case you need to loosen the sauce.

Step 3: Build the Sauce Base

In the same skillet, melt butter and add minced garlic. Sauté until fragrant, about a minute. Stir in Cajun seasoning and cook briefly to toast the spices.

Step 4: Add the Cream and Cheese

Pour in the heavy cream and bring to a gentle simmer. Stir in grated Parmesan and let it melt into a creamy sauce. If it’s too thick, add a splash of reserved pasta water.

Step 5: Combine and Finish

Return the cooked chicken to the skillet, along with the drained penne. Toss everything together until coated in the creamy sauce. Taste and adjust seasoning as needed. Serve hot, optionally garnished with extra Parmesan or chopped parsley.

How to Serve and Store Cajun Garlic Butter Chicken Penne

This dish is best served hot right out of the skillet when the sauce is at its creamiest and the chicken still juicy. It feeds about four people generously, making it a great family dinner or meal prep option. The bold flavors hold up well even as leftovers, and the pasta continues to absorb the sauce, intensifying the taste.

To store, let the dish cool completely before transferring to an airtight container. Keep it in the refrigerator for up to four days. Reheat gently on the stove or in the microwave, adding a splash of cream or milk if the sauce needs loosening.

What to Serve With Cajun Garlic Butter Chicken Penne?

Garlic Bread

A crusty, buttery garlic bread is perfect for sopping up extra sauce and keeping things indulgent.

Caesar Salad

The crisp romaine and tangy dressing offer a fresh contrast to the richness of the pasta.

Roasted Broccoli

A side of simply roasted broccoli with lemon adds a pop of brightness that complements the creamy, spicy flavors.

Sautéed Green Beans

Keep things vibrant and snappy with green beans cooked in olive oil and a pinch of sea salt.

Corn on the Cob

Sweet corn offers a fun, summery twist that pairs well with Cajun seasoning.

Parmesan Roasted Potatoes

Yes, more carbs—but the extra crunch from roasted potatoes with Parmesan is worth it.

Iced Tea or Lemonade

Balance the spice with a cold, refreshing drink like homemade lemonade or sweet iced tea.

Want More Chicken Pasta Ideas?

If you love this creamy Cajun Garlic Butter Chicken Penne, you might want to explore more flavorful pasta creations on Mia Plates:

Creamy Ground Beef Alfredo Pasta for a cozy, beefy twist on Alfredo.
Cheesesteak Tortellini in Rich Provolone Sauce if you love cheese-forward comfort dishes.
Stovetop Creamy Ground Beef Pasta that brings richness and ease in every bite.
One Pot Smoked Sausage Pasta when you want bold flavors and minimal cleanup.
Creamy Beef and Shells Recipe for a nostalgic, kid-friendly favorite.

Save This Recipe For Later

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And let me know in the comments how yours turned out. Did you add shrimp or extra heat? Did you swap the pasta shape?

I love seeing how others personalize their plates. If you have questions, ask away—I’m here to help make your kitchen experience a little easier and a lot tastier.

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