Creamy Cajun Chicken Linguine with Spicy Garlic Cheese Sauce

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There’s nothing like a comforting bowl of creamy pasta with a spicy kick to warm you up and satisfy your cravings. This Creamy Cajun Chicken Linguine with Spicy Garlic Cheese Sauce hits all the right notes—it’s rich, spicy, cheesy, and loaded with bold Cajun flavor that wraps around every strand of pasta. With tender seasoned chicken and a sauce that’s as velvety as it is spicy, it’s the kind of dish that turns an ordinary weeknight into a mini celebration.

Whether you’re cooking for the family, entertaining guests, or simply treating yourself to a flavorful meal, this recipe delivers comfort and complexity. The Cajun spices pack a punch without overwhelming the dish, while the garlic and cheese in the sauce bring balance and richness. Paired with a bit of crusty bread or a crisp salad, it becomes a restaurant-worthy dinner right from your kitchen.

Why You’ll Love This Creamy Cajun Chicken Linguine

This dish brings together the best of both worlds: spice and comfort. The Cajun seasoning gives it that signature Southern heat, while the creamy garlic cheese sauce tones things down just enough to keep you going back for more. It’s easy to customize, quick enough for a weeknight, and decadent enough for guests. You’ll love how the spicy chicken, garlicky sauce, and silky pasta all come together in one craveable bite.

What Kind of Cajun Seasoning Should I Use?

You can use your favorite store-bought Cajun blend, but if you like to mix things up, a homemade version works beautifully. Look for a seasoning that balances paprika, garlic powder, onion powder, thyme, oregano, cayenne, and black pepper. Be mindful of salt content, especially if you’re using salted butter or broth in the sauce. You want flavor, not salt overload. Want extra heat? Toss in a pinch of cayenne or crushed red pepper flakes right into the sauce.

Ingredients for the Creamy Cajun Chicken Linguine

To create this bold and creamy dish, you’ll need a few pantry staples and a few fresh ingredients. Each one adds a layer of flavor and texture that makes this pasta dish unforgettable.

Chicken breast

Linguine pasta

Cajun seasoning

Butter

Garlic cloves

Heavy cream

Cream cheese

Shredded cheddar cheese

Parmesan cheese

Olive oil

Salt and pepper

Fresh parsley (optional)

The seasoned chicken adds protein and spice, while the linguine acts as the perfect carrier for the creamy sauce. Garlic provides an aromatic base, while the cheeses and cream give you that ultra-silky, flavorful texture.

How To Make the Creamy Cajun Chicken Linguine

Step 1: Season and Sear the Chicken

Coat your chicken breast with Cajun seasoning on both sides. In a large skillet over medium-high heat, add a drizzle of olive oil and sear the chicken until it’s golden brown and cooked through, about 6-8 minutes per side depending on thickness. Set aside and let it rest before slicing.

Step 2: Cook the Pasta

Bring a large pot of salted water to a boil and cook the linguine according to the package instructions until al dente. Reserve about a cup of pasta water before draining.

Step 3: Make the Spicy Garlic Cheese Sauce

In the same skillet used for the chicken, lower the heat and add butter. Once melted, sauté the minced garlic until fragrant, about 1 minute. Add cream cheese and stir until melted and smooth. Pour in the heavy cream and whisk gently. Gradually stir in the cheddar and Parmesan until the sauce is fully melted and creamy.

Step 4: Combine Everything

Add the cooked linguine into the sauce, tossing to coat each strand evenly. If the sauce is too thick, add a splash of the reserved pasta water to loosen it up. Add the sliced Cajun chicken on top, spoon some extra sauce over the chicken, and finish with chopped fresh parsley if desired.

Serving and Storing This Creamy Cajun Chicken Linguine

This recipe makes enough to generously serve four hungry people, or six smaller portions if paired with side dishes. When serving, make sure each plate gets a good amount of the creamy garlic cheese sauce—that’s where all the magic is. Top it off with a sprinkle of fresh parsley and an extra pinch of Cajun seasoning if you like the heat dialed up.

If you have leftovers, they store beautifully in an airtight container in the fridge for up to 3 days. Reheat gently on the stove over low heat with a splash of milk or cream to bring back the creamy consistency. Microwaving works in a pinch, but be sure to stir halfway through to avoid cold spots.

What to Serve With Creamy Cajun Chicken Linguine?

Garlic Bread with Herb Butter

The sauce in this pasta is begging to be soaked up with something toasty. A buttery garlic bread will do just the trick.

Roasted Broccoli

Its crisp-tender texture and slight bitterness balance out the richness of the sauce perfectly.

Classic Caesar Salad

The cool crunch of romaine, creamy Caesar dressing, and shaved Parmesan provide a nice contrast.

Corn on the Cob

Grilled or boiled, the sweetness of corn complements the spice in the Cajun chicken.

Sautéed Green Beans

Quick to make and lightly seasoned, green beans bring a refreshing bite to your dinner plate.

Tomato Cucumber Salad

A chilled side with tangy vinaigrette brings acidity and freshness that cuts through the cream.

Fried Okra

A Southern staple that adds a bit of crunch and depth to any Cajun-inspired plate.

Want More Chicken Pasta Ideas?

If you’re into creamy, flavorful pasta dishes like this Creamy Cajun Chicken Linguine, here are a few more comforting favorites you can try next:

Stovetop Creamy Ground Beef Pasta is a one-pan wonder for busy nights.

Cheesesteak Tortellini in Rich Provolone Sauce brings a Philly-inspired twist with layers of cheesy goodness.

Creamy Ground Beef Alfredo Pasta is rich, savory, and full of comfort.

Creamy Beef and Shells Recipe is a hearty, kid-friendly favorite.

One Pot Smoked Sausage Pasta offers smoky flavor with minimal cleanup.

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📌 Save this recipe to your Pinterest dinner board so you can come back to it any time.

And let me know in the comments how yours turned out. Did you add mushrooms or swap the pasta? Did you turn up the heat?

I love hearing how others make these recipes their own. Questions are welcome too—let’s help each other cook better.

Explore beautifully curated pasta and chicken dinner recipes on Mia Recipes on Pinterest and find your next weeknight winner!

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