A plate of creamy Cajun chicken spaghetti is the kind of comfort food that turns any evening into a special one. This dish combines tender, juicy chicken with a silky, spiced cream sauce that clings to every strand of spaghetti. The garlic mozzarella sauce brings in that luscious cheesy pull, while the Cajun seasoning adds a smoky, slightly spicy kick that keeps each bite interesting.

It’s a meal that feels like it took hours to prepare, yet comes together surprisingly quickly, making it perfect for both busy weeknights and relaxed weekend dinners. Whether you serve it to impress guests or simply to treat yourself, the bold flavors and creamy texture make it a recipe you’ll want to keep in regular rotation.

Why You’ll Love This Creamy Cajun Chicken Spaghetti

This dish is the perfect balance of spice, creaminess, and comfort. The Cajun seasoning livens up the chicken without overpowering the rich garlic mozzarella sauce. It’s hearty enough to satisfy even the hungriest eaters, yet elegant enough to serve at a dinner party. Plus, the combination of pasta, tender chicken, and gooey cheese makes it a family favorite that appeals to both adults and kids.

What Kind of Cajun Seasoning Works Best?

Not all Cajun blends are created equal. Some lean heavier on the heat, while others focus more on smoky paprika and aromatic herbs. For this recipe, look for a seasoning that offers a well-rounded flavor—smoky, savory, and slightly spicy—without being overwhelmingly hot. If you prefer more control over the spice level, you can even make your own blend using paprika, garlic powder, onion powder, oregano, thyme, cayenne, and black pepper.

Ingredients for the Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce

This recipe calls for simple yet flavorful ingredients that come together to create a rich, satisfying dish. Each one plays an important role in building the layers of taste and texture that make this pasta irresistible.

Chicken breast – Lean, tender, and the perfect protein to carry the Cajun spices.
Spaghetti – The classic pasta choice that holds the creamy sauce beautifully.
Cajun seasoning – Brings smoky, spicy, and aromatic notes that define the dish.
Olive oil – For searing the chicken and adding depth to the sauce.
Garlic cloves – Fresh garlic infuses the sauce with savory warmth.
Butter – Creates a silky base for the sauce and enhances richness.
All-purpose flour – Helps thicken the sauce for a luscious, creamy texture.
Chicken broth – Adds savory depth and balances the creaminess.
Heavy cream – The key to the sauce’s luxurious consistency.
Mozzarella cheese – Melts into the sauce for that irresistible cheesy pull.
Salt and pepper – To bring all the flavors together.
Fresh parsley – Adds a pop of color and freshness before serving.

How To Make the Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce

Step 1: Season and Sear the Chicken

Pat the chicken breasts dry and season generously with Cajun seasoning, salt, and pepper. Heat olive oil in a large skillet over medium-high heat, then sear the chicken until golden brown on both sides and cooked through. Remove and set aside to rest.

Step 2: Cook the Spaghetti

Bring a large pot of salted water to a boil. Add spaghetti and cook until al dente according to package instructions. Drain and set aside, reserving a small amount of pasta water.

Step 3: Build the Sauce Base

In the same skillet used for the chicken, lower the heat to medium. Add butter and minced garlic, cooking until fragrant. Stir in the flour and cook for a minute to remove any raw taste.

Step 4: Create the Creamy Garlic Mozzarella Sauce

Gradually whisk in the chicken broth, then the heavy cream. Let the mixture simmer gently until it thickens slightly. Stir in the mozzarella cheese until fully melted and smooth.

Step 5: Combine Everything

Slice the rested chicken into strips. Toss the spaghetti into the sauce, adding a splash of pasta water if needed for extra creaminess. Add the chicken back into the skillet and gently mix.

Step 6: Garnish and Serve

Top with fresh parsley and an extra sprinkle of Cajun seasoning if desired. Serve immediately while hot and creamy.

Serving and Storing Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce

This recipe comfortably serves four people, making it ideal for a family dinner or a cozy meal with friends. For the best experience, serve it hot straight from the pan so the sauce remains silky and the cheese stretchy. Pair it with a side of warm bread or a crisp salad to round out the meal.

If you have leftovers, store them in an airtight container in the refrigerator for up to three days. To reheat, warm gently on the stovetop over low heat with a splash of cream or chicken broth to restore the sauce’s creamy texture. Avoid microwaving for too long, as it can cause the sauce to separate.

What to Serve With Creamy Cajun Chicken Spaghetti?

Garlic Bread

Crispy, buttery garlic bread is perfect for mopping up any leftover sauce on the plate.

Roasted Vegetables

A mix of roasted bell peppers, zucchini, and carrots adds a light, colorful balance to the rich pasta.

Caesar Salad

The crisp romaine, creamy dressing, and crunchy croutons offer a refreshing contrast to the creamy pasta.

Grilled Asparagus

Smoky, charred asparagus spears pair beautifully with the Cajun spices.

Caprese Salad

Fresh mozzarella, tomatoes, and basil drizzled with balsamic glaze bring a bright and tangy note.

Sautéed Green Beans

A quick side of green beans with garlic and olive oil keeps the meal fresh and vibrant.

Parmesan-Crusted Zucchini

Adds a savory crunch that works well alongside the creamy main dish.

Want More Pasta Dinner Ideas?

If you love this Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce, you’ll probably enjoy these other comforting pasta favorites from Mia Plates:

• Creamy Beef and Shells Recipe for a rich, meaty option.
• One-Pot Smoked Sausage Pasta when you want something smoky and savory.
• Creamy Ground Beef Alfredo Pasta for an ultra-creamy twist on a classic.
• Cheesy Baked Tortellini with Meat Sauce to satisfy your baked pasta cravings.
• Authentic Italian Style Spaghetti Bake Recipe for a hearty, oven-baked family meal.

Save This Recipe For Later

📌 Save this recipe to your Pinterest dinner board so you can come back to it anytime.

And let me know in the comments how yours turned out. Did you go heavy on the Cajun spice, or keep it mild? Did you try adding extra veggies to the mix?

I love hearing how others make these recipes their own. Questions are always welcome—let’s help each other cook smarter and tastier.

Explore beautifully curated health-boosting drinks and hearty meal ideas on Mia Recipes on Pinterest and discover your next go-to favorite!