Cajun Chicken Pasta in Creamy Parmesan Garlic Sauce

Save this recipe on:

When I think of comfort food with a bit of a kick, this Cajun Chicken Pasta in Creamy Parmesan Garlic Sauce is the very first dish that comes to mind. It marries bold, spicy flavors with a silky, cheesy sauce that clings perfectly to every bite of tender chicken and pasta. This is the kind of meal that warms you from the inside out, yet leaves you craving another serving.

I first made this recipe on a whim, trying to breathe new life into a basic chicken pasta dish. I tossed in Cajun spices, some heavy cream, and plenty of garlic and parmesan. The result? A masterpiece that instantly became a family favorite. It’s since become a go-to when I want something that feels indulgent but is incredibly easy to pull together on a busy weeknight.

If you’re someone who loves a rich sauce with a spicy edge, you’re in for a real treat. This dish is flavor-packed and feels restaurant-worthy, yet it comes together with pantry staples and minimal effort. And if you enjoy this, you might also love my One Pot Smoked Sausage Pasta or the creamy twist in my Creamy Ground Beef Alfredo Pasta. For another easy weeknight hit, don’t miss the Stovetop Creamy Ground Beef Pasta.

Why You’ll Love This Cajun Chicken Pasta in Creamy Parmesan Garlic Sauce

This recipe hits every high note: it’s creamy, spicy, cheesy, and filled with hearty protein. The Cajun seasoning adds a layer of smoky heat that’s beautifully balanced by the garlic-infused parmesan sauce. And the best part? It’s entirely customizable. You can add veggies like spinach or mushrooms, swap the chicken for shrimp, or adjust the spice level to fit your taste. It’s the perfect one-dish dinner when you need something quick but crave something extraordinary.

Ingredients

Chicken breast: The main protein in this dish. It soaks up all the Cajun seasoning and sears beautifully.

Cajun seasoning: Brings the signature spicy, smoky flavor to the recipe. Essential for creating that bold Southern-style taste.

Garlic: Freshly minced garlic adds a fragrant, robust base to the creamy sauce.

Heavy cream: Makes the sauce rich and velvety, perfectly coating every bite of pasta.

Parmesan cheese: Adds saltiness and depth to the sauce, giving it a sharp and creamy finish.

Butter: Used for sautéing and enriching the sauce.

Pasta: A sturdy pasta like penne or fettuccine holds the creamy sauce and makes every bite satisfying.

Salt & black pepper: Enhance all the other ingredients and balance the richness of the cream.

How to Make Cajun Chicken Pasta in Creamy Parmesan Garlic Sauce

Step 1: Season and Cook the Chicken

Season chicken breast slices generously with Cajun seasoning. In a large skillet over medium heat, melt a bit of butter and sear the chicken until golden on both sides and cooked through. Remove and set aside.

Step 2: Sauté the Garlic

In the same skillet, add minced garlic and cook for about 30 seconds until fragrant. Be careful not to burn it.

Step 3: Make the Cream Sauce

Pour in the heavy cream and bring it to a gentle simmer. Stir in the grated parmesan cheese and continue to stir until it melts into a smooth, creamy sauce. Season with salt and pepper to taste.

Step 4: Cook the Pasta

While making the sauce, boil your pasta according to package directions until al dente. Drain and set aside.

Step 5: Combine Everything

Return the chicken to the skillet and toss in the cooked pasta. Stir everything together so the sauce coats each strand of pasta and piece of chicken.

Step 6: Serve

Serve hot, garnished with extra parmesan or chopped parsley if desired. It’s best enjoyed fresh and piping hot!

Recipe Variations and Possible Substitutions

If you want to change things up, there are so many ways to tailor this recipe. Try swapping the chicken for shrimp or even smoked sausage for a different protein. You can lighten the sauce by using half-and-half instead of heavy cream or even coconut milk for a dairy-free twist. For added texture and nutrition, toss in vegetables like mushrooms, bell peppers, or spinach. And if you’re gluten-free, use your favorite gluten-free pasta without losing any of the bold, creamy flavor.

Serving and Pairing Suggestions

This Cajun Chicken Pasta is satisfying on its own, but it pairs wonderfully with a crisp green salad or roasted vegetables like broccoli or asparagus. A crusty garlic bread or homemade naan also makes the perfect sidekick to soak up every last bit of sauce. If you’re enjoying it with wine, a cold glass of Chardonnay or a slightly chilled Pinot Noir balances the spice and richness beautifully.

Storage and Reheating Tips

To store leftovers, place them in an airtight container and refrigerate for up to 3 days. The sauce may thicken as it sits, so when reheating, add a splash of cream or milk to bring it back to its original creamy consistency. Gently reheat on the stove over low heat or in the microwave in short bursts, stirring in between. Avoid freezing, as cream-based sauces can separate when thawed.

FAQs

Can I make Cajun Chicken Pasta in Creamy Parmesan Garlic Sauce ahead of time?

Yes! You can cook the components separately and combine them when ready to serve. Just keep the sauce and pasta refrigerated separately and reheat gently before mixing.

What type of pasta works best for Cajun Chicken Pasta in Creamy Parmesan Garlic Sauce?

Short pastas like penne, rigatoni, or even rotini are great because they hold the sauce well, but long pastas like fettuccine or linguine work beautifully too.

Can I use store-bought Cajun seasoning for Cajun Chicken Pasta in Creamy Parmesan Garlic Sauce?

Absolutely. Store-bought blends work fine, but you can also mix your own with paprika, garlic powder, onion powder, thyme, cayenne, and oregano if you want full control over the heat.

How spicy is Cajun Chicken Pasta in Creamy Parmesan Garlic Sauce?

It’s moderately spicy. If you prefer a milder version, reduce the Cajun seasoning or use a low-sodium, mild variety.

Is Cajun Chicken Pasta in Creamy Parmesan Garlic Sauce gluten-free?

Not by default, but it can easily be adapted by using gluten-free pasta and checking that your Cajun seasoning and other ingredients are gluten-free certified.

Related Recipe You’ll Like

If you can’t get enough creamy, satisfying pasta dishes, I highly recommend trying my Creamy Tortellini or the bold flavors in this Sticky Honey Garlic Steak Rotini. These are just as comforting, packed with flavor, and perfect for your next pasta night.

Save and Share This Recipe for Later

Love this Cajun Chicken Pasta in Creamy Parmesan Garlic Sauce? Be sure to pin it to your favorite dinner board on Pinterest so you can find it anytime. You can also share it with friends and family on Facebook, or send it via email to someone who needs a little dinner inspiration. It’s too good to keep to yourself!

Save this recipe on: